Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.
Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.
Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen
Feb. 2015WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited.
Feb. 2015Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts.
Jan., 2015Dkk1 haploinsufficiency requires expression of Bmp2 for bone anabolic activity.
Jan., 2015The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/β-Catenin Signaling
Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.
July 2014A novel signaling pathway regulates colon cancer angiogenesis through Norrin
Nov., 2014Harvard Researchers unveiled a novel Wnt signaling pathway controlling cancer metastases.
Oct., 2014CRISPR-mediated direct mutation of cancer genes in the mouse liver
Dec., 2013Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
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Ottawa Hospital Research Institute
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Xi He Lab
Department of Neurology
Harvard Medical School
Let's understand Wnt signaling pathways
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