Recombinant Wnt Signaling Ligands
Wnt ligand stabilizer
Mouse Wnt Protein Control
Wnt Signaling Receptors
The working concentrations of mouse Wnt3a for organoid culture
Copyright 2015. Time Bioscience. All Rights Reserved.
Wnt Ligand Stabilizer:
We proudly announce that we provide Wnt ligand stabilizer. the Stabilizer helps to maintain Wnt ligand activity for more than 30 hours in serum-free culture conditions.
Our Wnt ligands are intact, potent, and fully functional.
Potent: The Wnt3a has been proved three times more potent than any one else; 30 to 100 ng/mL for organoid formation;
Intact: These Wnt ligands are purified using a Wnt ligands-binding molecule-conjugated sepharose beads and size exclusion chromatography. The affinity chromatography yields a single pool with strong Wnt activity rather than two pools;
Fully functional: The size exclusion chromatography removes dimers and cleaved Wnt proteins. Compared to two Wnt peaks from affinity chromatography, the Wnt3a is fully functional.
We express and purify human Wnt3a from a special human cell line. Our human Wnt3a is as potent as the mouse one.
Lijian Hui Lab at Chinese Academy of Sciences, China - In Vitro Expansion of Primary Human Hepatocytes
with Efficient Liver Repopulation Capacity. Cell Stem Cell 23, 1–14, December 6, 2018
Ethan Lee lab at Vanderbilt -APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. Developmental Cell 44, 566–581 (2018)
Leslie S. Gewin Lab at Vanderbilt -Blocking TGF-b and b-Catenin Epithelial Crosstalk Exacerbates CKD. Journal of the American Society of Nephrology 28; 3490-3503 (2017)
Lawrence Lum's Lab at UT Southwestern Medical Center - PNAS Early Edition, J. Moon
Organizations who have proved our Wnt ligands